I take both Lamictal and rexulti. I am extremely allergic to Welbutrin (sent me to the hospital allergic). I have had good results with the rexulti. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. REXULTI is not approved for the treatment of. A Moderate Drug Interaction exists between Lamictal and Rexulti. View detailed information regarding this drug interaction. Hope this helps some. Article Sources. Find help or get online counseling now. Minor Minimally clinically significant. I believe it has a drug interaction with Wellbutrin as well.